Louisville at Duke rematch Monday tests ACC contenders as Blue Devils favored at home

Key ACC matchup set for Jan. 26 in Durham

No. 23 Louisville visits No. 5 Duke on Monday, Jan. 26, 2026, with tipoff set for 7 p.m. ET at Cameron Indoor Stadium in Durham, North Carolina. The game is scheduled to air on ESPN as part of the conference’s “Big Monday” slate.

The rematch comes 20 days after the teams first met this season in Louisville. Duke won that Jan. 6 meeting 84-73, rallying after trailing at halftime and using a decisive second-half run to pull away.

Current records, recent results, and why the game matters

Louisville enters the night 14-5 overall and 4-3 in ACC play. The Cardinals moved back above .500 in conference action Saturday with an 85-71 home win over Virginia Tech.

Duke brings an 18-1 overall record and a 7-0 mark in ACC games. The Blue Devils extended their conference unbeaten streak Saturday with a 90-69 home win over Wake Forest, a game in which Duke controlled the paint and the glass.

In the ACC standings, Duke’s perfect league start has positioned it among the conference front-runners, while Louisville’s early stretch has placed added importance on road opportunities against top-tier opponents.

Betting market snapshot: spread and total

As of early Monday, Duke opened as a clear home favorite. One widely posted line listed Duke -7.5 with a total of 157.5 points, while other major market boards showed Duke favored by 6.5 points. The total reflects two teams that have produced high-scoring performances but also shown the ability to separate games with defense and rebounding.

• Game: Louisville at Duke
• Date/time: Monday, Jan. 26, 2026, 7 p.m. ET
• Location: Cameron Indoor Stadium (Durham, North Carolina)
• Broadcast: ESPN

What the first meeting revealed

The Jan. 6 game at the KFC Yum! Center showed how narrow margins can swing quickly in this matchup. Louisville led 47-38 at halftime, but Duke outscored the Cardinals 46-26 after the break to win by 11. Duke’s Cameron Boozer posted 27 points and eight rebounds, with Isaiah Evans adding 23 points. Louisville was led by Ryan Conwell (24 points) and Aly Khalifa (17 points).

Series context and home-court history

Duke holds an 18-9 advantage in the all-time series. At Cameron Indoor Stadium, Louisville has won three of eight meetings. Duke has won the last eight matchups overall, with Louisville’s most recent win in the series coming in overtime at Duke on Feb. 27, 2021.

The rematch pairs one of the ACC’s hottest starts with a Louisville team seeking a defining road result after an uneven conference opening.